Atrial fibrillation prevention and treatment of ischemic stroke Progress.docVIP

 PAGE \* MERGEFORMAT 13 Atrial fibrillation prevention and treatment of ischemic stroke Progress [Keywords:] atrial fibrillation, ischemic stroke, anticoagulant therapy Atrial fibrillation (Af is a common sustained arrhythmia, with age, its incidence increased significantly. Af is an independent risk factor for stroke, especially in the elderly population, stroke has become the main reason for increased mortality Af . Af therapy has three main objectives: control of ventricular rate, cardioversion and maintenance of sinus rhythm, and prevention of thromboembolic events. and Af arrhythmia prevention is still the current treatment of the weakest link, but also cardiovascular 21 a major problem area. Modern studies suggest that all patients with atrial fibrillation to sinus rhythm should be given as much as possible the treatment of ischemic stroke should be given active treatment such as anticoagulation and thrombolysis. now in recent years, complicated by ischemic stroke Af Advances in prevention and treatment were reviewed. fibrillation caused by the mechanism of ischemic stroke in Af prothrombotic state [1] (Prothrombotic State, PTS is caused by many factors imbalance between coagulation and fibrinolysis system of a pathological process, prone to thrombosis and other hematological changes. Some scholars from many aspects of PTS were studied. mainly prothrombotic state in Af blood parameters: High-Low anticoagulation status of coagulation [2]: the process of prothrombin activation can be released from clotting plasminogen fragment 1 +2 (F1 +2, the rapid formation of thrombin and antithrombin (AT with the formation of thrombin antithrombin complex (TAT, and thrombin cleavage of fibrinogen (Fg generate fibrinopeptide A (FPA that the F1 +2, TAT, FPA are sensitive indicators reflecting the formation of thrombin. AT is the most important anticoagulant in vivo, 70% to 80% inactivation of thrombin, AT deficiency and / or decrease in activity is thrombosis, i