B-type natriuretic peptide in clinical application of advances in cardiovascular disease.docVIP

 PAGE \* MERGEFORMAT 12 B-type natriuretic peptide in clinical application of advances in cardiovascular disease [Keywords:] cardiovascular disease B-type natriuretic peptide (brain / B-typenatriuretic peptide, BNP 80 in the 20th century, first proposed by the Sudoh, etc., because of its first isolated from porcine brain is also known as brain natriuretic peptide. The main synthesis and secretion from the ventricle, in human plasma in the ring structure contains 32 specific peptide form. natriuretic peptide receptor by binding to its major biological role. now found in A, B, C 3 natriuretic receptor (NPR, in large A receptor in blood vessels common to brain tissue is mainly B-type receptors, C-type receptors are present in the kidney and blood vessels [1]. Beware of rooms increased pressure or volume expansion, its secretion has also come to increase and expansion of blood vessels, excess water from the kidneys, reduce fluid retention, lower blood pressure and reduce the burden on the heart. phosphorylation / dephosphorylation is an important mechanism for regulating activity of NPR [2]. BNP in vivo half-life of 22min, mainly in the degradation of the lung, and kidney. BNP major role in the endothelial cells and vascular smooth muscle cell-specific receptor to activate adenylyl cyclase, increasing intracellular second messenger cyclic guanosine monophosphate levels, thereby promoting diuresis, natriuresis, peripheral expansion, reduce renin angiotensin, aldosterone and epinephrine, and endothelin system activity and reduce the volume load. BNP still adjust the autonomic nervous system, blockade of myocardial fibrosis and the role of vascular smooth muscle cell proliferation, but also inhibit the expression of tissue factor in vascular endothelial cells (eg endothelial factors and plasminogen activation inhibitor I expression, to prevent thrombosis congestive state [3]. A clinical role 1.1 B-type natriuretic peptide in the diagnosis of heart fail