Bone marrow mesenchymal stem cell transplantation for treatment of lumbar disc degeneration progress.docVIP

 PAGE \* MERGEFORMAT 13 Bone marrow mesenchymal stem cell transplantation for treatment of lumbar disc degeneration progress Study: Fan Shougang, Wang Yuntao, Wu Xiaotao [Keywords:] disc degeneration, bone marrow mesenchymal stem cells, tissue engineering, literature review Disc degeneration (intervertebral disc degeneration, IDD) is a common cause of low back pain caused by one common clinical lumbar disc disease and spondylolisthesis, etc., seriously affecting people’s quality of life. The current treatment of major biological functions of protection and mitigation are symptoms, not from the lifting of the pathophysiology of disease risk factors, often lead to recurrence of in situ or adjacent disc disease [1]. Since the introduction of bone marrow mesenchymal stem cells (bone marrow mesenchymal stem cells, BMMSCs) concept has been using its repair tissue damage and promote functional recovery treatment of the role of the medical field as one of the hotspots of most concern. at home and abroad have a cell culture, small animal and large animal experiments demonstrated this approach from many angles, but have not yet reached clinical trials stage. of New Progress in this field are reviewed. 1 BMMSCs transplantation in the treatment of lumbar IDD 1.1 BMMSCs the Feasibility Study the feasibility of transplantation in the treatment of lumbar IDD IDD is often accompanied by nucleus pulposus (NP cells and annulus fibrosus (AP) cells, reduced to their regeneration is the key to biological treatment of IDD, but the small number of two cells, regeneration and self-renewal capacity of poor and not suitable Tissue Engineering. Risbud et al [2] IDD patients from 5 patients with lumbar intervertebral disc cells were cultured in isolation, by analyzing cell surface markers, protein expression and cell mRNA synthesis and found that the NP and AP activities in cell differentiation of cells signs of disc degeneration demonstrated in the presence of ancestor cel