Bone Qili San soft capsule plus wet ultrafine grinding technology of PEG400.docVIP

 PAGE \* MERGEFORMAT 13 Bone Qili San soft capsule plus wet ultrafine grinding technology of PEG400 [Abstract] Objective wet ultrafine grinding technology of bone Qili San formulation of the reform process improvement and to study bone Qili San soft capsule best wet ultrafine grinding process parameters. Approach to particle size (D50 and D90 , the material stability for the indexes, using single factor respectively on the dispersion medium, medium dosage of filter parameters. Results soft capsule best wet ultrafine grinding process: pre-heat at 1.5 times the amount of PEG400 , 40 ultrafine grinding the following 35 min, the material, that is, too. Conclusion wet ultrafine grinding process is simple, efficient, not only fining particle size increases the bioavailability of drugs, saving medicine source, while the materials are higher degree of quality, ease of preparation, have broad application prospects. [Keywords:] bone Qili San soft capsule, wet ultrafine grinding, PEG400, bioavailability Abstract: ObjectiveTo explore the optimal ultra-fine pulverization procedure for the content of Jie Gu Qi Li San soft capsule by wet processing. MethodsUsing the particle size (D50 and D90), station and so on of the contents from Jie Gu Qi Li San soft capsule as main indicators, the pulverization progress was studied by single factor method. In this way, the effects of such conditions as pulverizing time, mediator consumption, pulverizing temperature and so on extracting rate were investigated.ResultsThe optimal pulverization procedure for the content of Jie Gu Qi Li San soft capsule was 1.5 times of PEG400, vibrating frequently 35 minutes under 40 . ConclusionThe optimum pulverizing procedure is convenient, and applicable to the preparation of Jie Gu Qi Li San Soft Capsule.It should have a good future. Keywords:: Jie Gu Qi Li San soft capsule; Frequent vibrating pulverization by wet processing; PEG-400; Bioavailability Bone Qili San (frankincense (system