Branch expansion Mixture of bronchiectasis in rat neutrophil elastase the role of.docVIP

 PAGE \* MERGEFORMAT 5 Branch expansion Mixture of bronchiectasis in rat neutrophil elastase the role of Author: Wu Qi-biao, Sun-kai, CAO Shi-hong, WAN Yi-gang [Keywords:] branch expansion Mixture;,, bronchiectasis;,, experimental study;,, animal model,;,, neutrophil elastase, Abstract: Objective: To study the branch expansion Mixture model of bronchiectasis neutrophil elastase (NE) the role of branch expansion Mixture efficacy mechanism. METHODS: SD rat model of bronchiectasis observed respiratory tract washing fluid neutrophil elastase content and branch expansion Mixture change after the intervention to explore the pathogenesis of bronchiectasis in their position and support expansion of the intervention effect Mixture . Results: The branch expansion Mixture significantly lower NE content (P amp;lt;0.01). Conclusion: The branch expansion Mixture can significantly reduce the airway bronchiectasis in NE release, inhibit its proteolytic activity, which may be one of the mechanisms of its efficacy, the value of further research and development. Keywords:: branch expansion Mixture; bronchiectasis; Experimental study; animal model; neutrophil elastase Effect of Zhikuoning Decoction on Neutrophil Elastase of Animal Model with Bronchiectasis Abstract: Objective: To investigate the role of neutrophil elastase (NE) in the pathogenesis of bronchiectasis and the effect of Zhikuoning Decoction (a TCM prescription) on it; to assess and explain the therapeutical efficacy of Zhikuoning Decoction on bronchiectasis.Methods: Animal model was established by intra-bronchial injection with Pseudomonas Aeruginosa.The effect of Zhikuoning Decoction on animal model was investigated by analyzing NE content in BALF and the change of it after being treated with Zhikuoning Decoction, compared with ofloxacin.Results: Zhikuoning Decoction is better than ofloxacin to lower NE. Conclusion: Zhikuoning Decoction has satisfactory effect in lowering the release of NE, thus suppressing its