Children chemotherapy plus imatinib mesylate Bcrabl fusion gene-positive adult acute lymphoblastic leukemia.docVIP

 PAGE \* MERGEFORMAT 8 Children chemotherapy plus imatinib mesylate Bcrabl fusion gene-positive adult acute lymphoblastic leukemia Of: Peng Lihui Hu light Ming Wang Sanbin [Abstract] Objective To analyze the children’s chemotherapy plus imatinib mesylate treatment of adults with bcr / abl fusion gene-positive acute lymphoblastic leukemia (ALL) patients in the remission rate and long-term survival of the state. Methods 10 patients, median age 30 years old (19 ~ 71 years) years, diagnosed by the MICM classification bcr abl-positive ALL. herein are BFM 90 chemotherapy plus imatinib mesylate treatment. Results All patients achieved complete remission with a median follow-up time was 20 months (4 to 24 months), 6 patients continued to CR.3 cases were complete cytogenetic response. Conclusion chemotherapy plus imatinib mesylate significantly improved Nicole to bcr / abl fusion gene positive ALL patient prognosis. [Keywords:] leukemia, bcr / abl fusion gene, clinical features, prognosis Bcr abl fusion gene-positive acute lymphoblastic leukemia (ALL) accounted for 20% of adult ALL approximately 30%, the prognosis is poor [1]. Although modern chemotherapy can achieve about 80% to 90% complete remission rate, but the adult long-term survival of patients was less than 10% [2]. BFM90 program [3] is a mature treatment of children with ALL treatment programs, access to disease-free survival rate of 80% good results. The program plus imatinib mesylate Treatment of Bcr abl fusion gene-positive adult ALL has not been reported at present. now our department from January 2005 to September 2008 10 patients were treated Bcr abl fusion gene-positive adult ALL reported below. 1 Materials and Methods 1.1 General Information Data from our hospital from January 2005 to September 2008, 54 cases of adult ALL were treated in 10 cases of bcr / abl fusion gene positive for the same period 18.5% of patients with newly diagnosed ALL (10 / 54). Including 6 males and 4 femal