Children subcutaneous panniculitis-like T cell lymphoma clinicopathological_0.docVIP

 PAGE \* MERGEFORMAT 14 Children subcutaneous panniculitis-like T cell lymphoma clinicopathological [Abstract] Objective To study the subcutaneous panniculitis-like T cell lymphoma clinicopathologic features, immunophenotype, gene rearrangement, and prognosis. Methods According to the 2005 WHO-EORTC classification of SPTCL clearly defined diagnostic criteria, were treated in our hospital 1 case SPTCL clinical manifestations, histological features, immunohistochemical results, T cell receptor (TCR) gene rearrangement, and prognosis, and related literature was reviewed. The results profiled in the subcutaneous tissue on the lymphatic adipocyte-like cells formed around a single characteristic lace-like structure. immunohistochemical staining of tumor cells: CD3, CD5, CD8, CD45RO, GranzymeB, TIA-1, did not express CD20, CD30, CD79a, CD56, PCK, TCR gene rearrangement Pai said: TCR gene rearrangements JV (-), JV (-); TCR gene rearrangement JD1 (+), JD2 (-) support for @ T cell origin of lymphoma, patients were followed up for 8 months in complete remission. Conclusions SPTCL is a rare origin @ / -type cytotoxic T cells in cutaneous lymphoma, the tumor T-cell lymphoma is inert, its protracted course of recurrent, early treatment and good prognosis, immunohistochemistry and gene rearrangement of SPTCL The accurate diagnosis is essential. [Keywords:] panniculitis, T-cell lymphoma, lace-like arrangement, gene rearrangement Abstract Objective To study the clinicopathological features, the immunophenotyping, the gene rearrangement and the prognosis of subcutaneous panniculitis-like T-cell lymphoma (SPTCL). Methods Based on the diagnosing criteria for SPTCL in WHO-EORTC Classification made in 2005, an analysis was made to the clinical manifestation, the histopathlogical features, the results of immunohistocheical study, TCR clonal gene rearrangement and the prognosis of 1 case with SPTCL; the related literature was reviewed.Results The histological study revealed