Childrens adverse drug reactions and related factors.docVIP

 PAGE \* MERGEFORMAT 15 Children’s adverse drug reactions and related factors [Keywords:] Children’s adverse drug reactions related factors In China, population aged 0 to 18 accounted for nearly 1 / 3 of the population, including the neonatal period, infant and early childhood, preschool, school age and adolescence, is the growth and development of the most productive groups. This age group, on the one hand due to various organs, physiological function is not yet mature, immune function lower the defensive capabilities to the outside world less invasive, more susceptible to disease than adults; the other hand, drug-metabolizing enzymes due to inadequate or lack of secretion, renal function imperfect development of drug clearance is poor; the same time, they lack self-awareness, when adverse drug reactions (ADR) occurs, the lack of ability to protect themselves, so they are more susceptible to ADR. China each year tens of thousands of children are hearing loss, of which more than 60% of drug-induced. One involving seven countries in 17 prospective observation of children’s ADR reporting Meta-analysis showed that 2.09% of children hospitalized due to ADR, which is 39.3% of them life-threatening; in hospitalized children, ADR incidence rate of 9.53%, 12.29% of them as a serious ADR; out-patient children ADR incidence 1.46% [1]. Children’s ADR has become a worldwide public health problem, therefore, to carry out ADR monitoring in children is especially important. In this paper, the children in our hospital to collect ADR analyze its risk factors, drug factors and pharmacists to reduce or avoid the ADR should be done in order to provide a reference for clinical health workers, improve drug safety. A children’s hospital ADR occurrence In our hospital since 1993 to carry out ADR monitoring until December 2007 were received by the medical officer’s report on children ADR reports 385 copies, accounting for the total ADR reports in our hospital 10.7% (385/3615). Thes