Chinese medicine on the stasis Tongluo renal tissue of diabetic nephropathy expression of CTGF mRNA.docVIP

 PAGE \* MERGEFORMAT 12 Chinese medicine on the stasis Tongluo renal tissue of diabetic nephropathy expression of CTGF mRNA On: Yoon Ji Wei Gao Junjie Chen Zhiqiang Sun Yufeng Ding Qifeng Yue-Hua Wang Jiang-Hua Zhang [Abstract] observed Huayu Tongluo medicine - Shenluotong on rat diabetic nephropathy (DN) model of renal function, connective tissue growth factor (CTGF) mRNA expression. Methods 40 SD rats were randomly divided into normal group, model group, control group and TCM group, model group, control group and TCM group received streptozotocin (STZ) 60 mg / kg intraperitoneal injection of rat diabetes model. Shenluotong TCM decoction group was given fed 25 g / (kg · d), the control group were given aqueous solution of benazepril 10 mg / (kg · d), the normal group and model group were given equal amount of 0.9% sodium chloride injection gavage. to detect the large mice 24 h urine protein, blood urea nitrogen (BUN), creatinine (Cr) and renal expression of CTGF mRNA. Results of model group 24 h urine protein, BUN, Cr and renal expression of CTGF mRNA were significantly higher than the normal group ( P lt;0.01), control group and TCM group 24 h urine protein, BUN, Cr and renal expression of CTGF mRNA compared with the model group were significantly lower (P lt;0.01). Conclusion Huayu Chinese medicine can significantly reduce network DN Models mice 24 h urine protein, renal function protection of DN rats, and from the gene was significantly lower renal expression of CTGF, suggesting that CTGF expression may be down Huayu Tongluo DN model of Chinese medicine to protect an important mechanism for renal function. [Keywords:] Diabetic nephropathy Renal connective tissue growth factor SD [Abstract] Objective To observe effects of dispersing blood stasis and dredging collateral-Shenluotong on renal function and expression of CTGF mRNA in diabetic nephropathy (DN) rats’ kidney.Methods The rats were randomly divided into four groups including normal group