Chronic obstructive pulmonary disease airway remodeling Research.doc

 PAGE \* MERGEFORMAT 25 Chronic obstructive pulmonary disease airway remodeling Research Keywords: chronic obstructive pulmonary disease airway remodeling Research Chronic obstructive pulmonary disease (COPD) global disease now ranks No. 4 cause of death, is today one of the major diseases that endanger people’s health. Airway remodeling (airwayremodeling) is a major pathological feature of COPD, which can cause airway obstruction and lung recoil power drops, in the airflow limitation played a very important role in [1]. A definition of airway remodeling Damage due to various factors that led to repeated stimulation of airway structural cells and inflammatory cells interact, causing airway smooth muscle hyperplasia and abnormal extracellular matrix deposition, the wall fibrosis. Airway remodeling is airway structural changes in the organization can be divided into the normal airway growth and development (appropriate remodeling) and abnormal / excessive changes in airway structure and function (inappropriate remodeling) [2]. The former mainly refers to normal growth and development and the acute inflammatory response to injury, the latter due to repeated injury and chronic inflammation caused by incomplete restoration of structure and function abnormalities. COPD patients with gas-pass the site of widespread remodeling in the atmosphere Road, airways, lung parenchyma, interstitial lung, including the pulmonary vascular structure and organization of both components changes. Bronchial lung tissue inflammation, injury, repair and reconstruction is the continuous progress of the pathological process of COPD, and airway remodeling in COPD patients is the main reason for symptoms and airflow obstruction. 2 Pathological changes in airway remodeling Pathological changes of airway remodeling, including thickening of the airway wall, epithelial lower fibrosis, smooth muscle hypertrophy, muscle fibroblast cell proliferation, mucous