Clindamycin phosphate as emergency prophylaxis of infection in trauma.docVIP

 PAGE \* MERGEFORMAT 7 Clindamycin phosphate as emergency prophylaxis of infection in trauma Of: Xu Pengjie, FORCES, Zhu Zhi Li, has the United States, Zhou Min, Tan Chang-sub, He Min [Abstract] Objective clindamycin phosphate emergency trauma infection prophylaxis, as efficacy and side effects. Methods in our department in January 2009 to June application of clindamycin phosphate and sodium cefazolin emergency trauma prevention patients with postoperative infection into the sample 1 and sample 2, and the number, in accordance with the random number table, randomly selected from 30 patients, respectively, as the observation group and the control group. observation group patients after application of clindamycin phosphate 0.6 g / 250 ml normal saline, bid, treatment for 6 days, the control group patients received cefazolin 2 g / 250 ml normal saline, bid, treatment for 6 days. were observed in both groups of patients the efficacy and adverse reactions. Results There was method no significant difference in efficacy (Pgt; 0.05, all good, local pain group were significantly different (P lt;0.05, other adverse reactions were no significant differences (Pgt; 0.05. Conclusions of clindamycin phosphate to prevent infection after trauma good efficacy, fewer minor adverse reactions, safety is high. [Keywords:] emergency trauma; infection; clindamycin phosphate Clindamycin phosphate by means of chemical reaction of clindamycin phosphate product with, no antibacterial activity in vitro, clinical medicine into the body, it is rapidly hydrolyzed clindamycin, showed its pharmacological activity. G Lin ADM mainly Gram-positive and anaerobic bacteria has a strong antibacterial activity, it is converted in the body has a strong antibacterial activity of N-demethyl Ji Kelin ADM, a major role in bacterial ribosomal 50S sub- base, thereby preventing the extension of peptide chains, inhibit bacterial protein synthesis [1], to prevent bacterial growth and reproduction, so