Clinical application of matrine.docVIP

 PAGE \* MERGEFORMAT 13 Clinical application of matrine Abstract matrine is a traditional Chinese herbal medicine Sophora the main active ingredient is the alkaloid, usually Sophora alkaloids, composition mainly matrine, Oxymatrine, Sophocarpine, oxysophocarpine, Sophora japonica fixed base, so as to matrine, the highest content of oxymatrine, with anti-virus and regulation of immune function and clinical forms of commonly used injections, according to the medical profession at home and abroad for many years studies have shown that matrine on the treatment of chronic hepatitis B hepatitis, gastrointestinal tumors and in psoriasis skin a significant effect. Keywords: chronic hepatitis B gastrointestinal cancer psoriasis matrine Matrine from Sophora species legume roots, stems, leaves of fruit and other organic solvent extraction by ethanol made from alkaloids, generally Sophora alkaloids, composition mainly matrine, oxymatrine, Sophora japonica fruit alkali, oxysophocarpine, sophoridine, so as to matrine, the highest content of oxymatrine. Mainly used to treat cancer, viral hepatitis, heart disease (such as viral myocarditis), as well as psoriasis and eczema skin (psoriasis and eczema) and so on, clinical result is good, now the clinical application of matrine and pharmacological summarized as follows : A clinical application of matrine and pharmacological 1.1 The inhibitory effect of matrine on tumor cells MA Ling-Di [1] and so on through the MTT determination of matrine on the proliferation of tumor-bearing mice in vitro PBMC Effect; ELISA assay after treatment of matrine in mice serum IL2 and IL12 activity. The results showed that: matrine in mice significantly inhibited tumor cell division and proliferation in vitro, and the inhibition was concentration and time-dependent, so that G1 phase cells increased, S phase and G2 / M phase cells decreased, cell proliferation index decreased . Effect of matrine on the growth of solid