Clinical Research of the plateau Gout.docVIP

 PAGE \* MERGEFORMAT 15 Clinical Research of the plateau Gout Of: Zhang Zhigang, Li Suzhi, Yang Yongqin, Liu Guoqing, Zou close [Keywords:] plateau, gout, clinical research Gout is the plateau at an altitude of 3,000 meters above areas, as the cause of hereditary or acquired due to purine metabolism, uric acid increased tissue damage with a group of diseases in clinical practice, including primary and secondary gout gout. Nearly With several years developing the western region, the population at high altitude increases, the incidence of gout increased year by year plateau. In order to further study the pathogenesis of gout plateau, clinical features, drug therapy, now the plateau in recent years, Clinical Research of gout are summarized below. 1 Pathogenesis 1.1 Modern Medicine [1] that About 10% of primary gout is caused by increased production of uric acid, about 90% was due to a decrease in uric acid excretion. Uric acid excess: Purine metabolism enzymes gene mutations in some of the changes in activity of serum uric acid rise eventually high, for example, hypoxanthine guanine phosphoribosyl transferase (HPRT and 5 - ribose -1-- pyrophosphate (PRPP synthetase (PRS. decreased excretion of uric acid: Uric acid is the end product of purine metabolism, mainly by the kidneys and intestinal tract in vitro by renal excretion is the main pathway, whereas urate transporter proteins involved in proximal tubule secretion of uric acid salts and re-absorption of the active, the gene variation may be important hyperuricemia pathogenesis. recent research focus is human urate anion exchanger, human urate transporter, hOAT1, hOAT3, MRP4, THP and other uric acid transporters. 1.2 Ganli Yu et al [2] that Cause of secondary gout Plateau and the Plateau caused by secondary polycythemia on blood uric acid increased. Gao Hong disease causes of elevated serum uric acid may be: First, red blood cells in plasma uric acid concentration of about half of that i