Clock gene and cardiovascular diseases.docVIP

 PAGE \* MERGEFORMAT 20 Clock gene and cardiovascular diseases [Abstract] the latest genetic research on the biological clock were reviewed. Focuses on the recent clock genes through its own transcription, translation and regulation of circadian rhythm in the process of formation. Introduced recently clock genes in the cardiovascular system in an important position. [Keywords:] clock; gene; Cardiovascular disease; time biology Numerous studies show that life on Earth, from single cell organisms such as bacteria, to the higher organisms (such as human) life events are the characteristics of the existence of biological rhythms, especially in circadian rhythm (circadian) [1-3]. These organisms rhythm is produced on Earth in order to adapt their living environment, the cycle of changes (such as changes in the Earth day and night, seasons) Evolution through continuous evolution and the formation of the inherent rhythm of the body, it is called the inherent endogenous rhythm. in recent years on the body’s biological rhythms have been the material basis of a very in-depth study, and has made considerable progress, especially in 1997 when King DP et al [4] cloned the first mammalian clock gene clock today, the next ten years, recently clock genes continue to be discovered and cloned, and how these genes transcription, translation and regulation of the formation of self-excited oscillation of circadian rhythm of the process also continue to be elucidated. near the gene in the maintenance of normal physiological function and the occurrence and development of some diseases the role played by the constantly revealed and explained. 1 Recently, Circadian clock genes and the resulting process Recently, a group of clock genes is through its own transcription, translation, feedback regulation of self-oscillation caused by the composition of the gene. At present the recent clock gene oscillation generated from a description of circadian rhythm of many, such as bac