Coating technology in the application of cardiopulmonary bypass device and its significance.docVIP

 PAGE \* MERGEFORMAT 10 Coating technology in the application of cardiopulmonary bypass device and its significance [Keywords:] coating technology; cardiopulmonary bypass; artificial material 1963, Gott et al [1] for the first time made of heparin-coated, its anticoagulant properties be recognized. Heparin coating of the invention initially is to improve the cardiopulmonary bypass (cardiopulmonary bypass, CPB) caused by blood clotting response, but with the progress of the study, it was discovered that heparin coating also can inhibit the activation of blood components to reduce the release of inflammatory factors such as characteristics of can significantly alleviate the inflammatory response after CPB [2-5], coating technology, thus the reduction of the inflammatory response after cardiac surgery, a hot spot. Currently on the market has a variety of heparin-coated products, their composition and principles are different. At the same time, various non-heparin-coated and other coating technologies are also actively developing or have been put into clinical use, their performance compared with the heparin-coated each has its advantages. A heparin coating technology 1.1 Duraflo Ⅱ coating (Baxter Inc.) Main components of heparin - Bian Amantadine - chloride complexes, the Department of ionic bonding methods. Duraflo Ⅱ coating can reduce fibrinogen adsorption, and then to prevent platelet activation, adhesion and removal; and anti-thrombin Ⅲ interaction, preventing Ⅻ a factor and kallikrein start blood contact reaction, inhibit blood coagulation, fibrinolysis and the complement system activation and ultimately ease the body’s inflammatory response; in CPB, blood contact with the loop to form a stable double-decker biocompatible surface structure similar to human endothelial surface. 1.2 Carmeda Bioactive Surface-coated (CBAS) (Medtronic Inc.) Major components of the heparin molecules and hydrophilic substrate layer, the Department of ‘end-point attachment