COL1A2 gene polymorphism and the relationship between childrens dental fluorosis.docVIP

 PAGE \* MERGEFORMAT 2 COL1A2 gene polymorphism and the relationship between children’s dental fluorosis Author: Huang, Jia Xin-mei, LI Shi-hong, YAN Ping-Ping, Cheng Xue-Min, Cui Liu-xin, Pakistan on [Keywords:] I collagen; dental fluorosis; gene polymorphism Abstract: Objective To investigate the type I collagen α 2 chain (COL1A2) Pvu Ⅱ genotype in drinking water, fluorine, iodine concentration of children in different parts of the distribution of COL1A2 Pvu Ⅱ polymorphism and the relationship between children’s dental fluorosis. Methods Polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP) method of detecting iodine fluoride normal zone, a simple high-fluoride area and the high fluoride iodine District 8 to 12-year-olds COL1A2 Pvu Ⅱ genotype. Dean’s method checks children’s dental fluorosis prevalence. The results of three area children COL1A2 Pvu Ⅱ genotype the normal geographical distribution of iodine in fluorine frequencies were PP233%, Pp367%, pp400%; simple frequency distribution of high fluoride areas, respectively PP98%, Pp451%, pp451%, Frequency Distribution of fluorine iodine respectively PP137%, Pp384%, pp479%, 3 Distribution of no statistically significant difference (χ 2 = 5191, P