Commonly used antibiotics and infusion solution stability.docVIP

 PAGE \* MERGEFORMAT 13 Commonly used antibiotics and infusion solution stability [Paper Keywords:] antibiotics; stability; compatibility [Abstract] To observe the compatibility of the stability of commonly used antibiotics. At room temperature under the conditions of compatibility of commonly used antibiotics after clinical content changes, and observe the compatibility of liquid and the pH value changes the appearance. A certain temperature and time, colorless mixture of clarity, no color change, bubbles generated and visible precipitation generation, pH, stability, and then the tips of drug compatibility unreasonable chemical changes can be compatibility; the contrary, its poor stability after compatibility At present a wide range of clinical antibiotics, common salt dissolved in the fluid injection compatibility with other intravenous drip treatment [1]. To this end we simulate the clinical drug concentrations of antibiotics commonly used for injection with common infusion solutions inspect compatibility stability, strengthen the clinical evaluation of drugs for clinical medicine to provide guidance to ensure the drug is reasonable, effective application. An instrument and reagent UV-2401 UV spectrophotometer (Shimadzu); TG328B-type electro-optical analytical balance (Shanghai Balance Instrument Factory); pHS-3C-type digital pH meter (Shanghai Lida Instrument Factory); antibiotic reference substance (China Pharmaceutical and Biological Products provided); antibiotic injection (Yangtze River Pharmaceutical Group Co., Ltd.). 2 Methods 2.1 Determination of the wavelength you choose to add a variety of appropriate reference standards, preparation of about 8 μ g / ml of antibiotic solution, and about 12 μ g / ml of the compatibility solution to distilled water blank, respectively, in the 200 ~ 400 nm wavelength range scans. According to a variety of solution at maximum absorption wavelength was chosen to examine the wavelength, using solutions