Compound Shouwu particles in hyperlipidemic rat mesenteric microcirculation.docVIP

 PAGE \* MERGEFORMAT 6 Compound Shouwu particles in hyperlipidemic rat mesenteric microcirculation Author: Zhang Hongxin Shi Changshun Wang Liang Lian Hai-Chen Lu Shulan Sun Shumin Yang Hongli [Abstract] Objective To explore the Chinese herbal compound granule on Gao Shou Wu lipemia serum lipids and mesenteric microcirculation, providing a scientific basis for clinical medicine. Methods 60 Wistar rats were randomly divided into normal control group, 10, building modules 50. Making modules for high-fat feed, 30 d, after the success of modeling were randomly divided into model group and compound Shouwu fat particles of high, medium and low-dose group, positive medicine control group. Were given normal saline, compound Shouwu particles of high, medium and low dose and fed gypenosides tablets for 4 weeks were observed in experimental animals after administration of various indicators of lipid and mesenteric microcirculation changes. The results of model group, serum TC, TG, LDL-C were significantly higher than the normal group, HDL-C was significantly lower than groups; mesenteric microcirculation observed that the treatment group, blood vessel diameter, blood flow velocity was significantly higher increase of blood fat, a marked increase in the number of capillaries open. Conclusion The compound Shouwu particles can be significantly reduced Gao lipemia serum lipids and improve their mesenteric microcirculation. [Keywords:] compound Shouwu particles hyperlipidemia microcirculation Hyperlipidemia is one of the clinical common diseases, is linked to cardiovascular disease, fatty liver, kidney disease an important risk factor. With the continuous improvement of people’s living standards, diet and lifestyle, significant changes in population trends in serum lipid level was increased year by year, the normal population the incidence of hyperlipidemia was 20% ~ 30% [1]. Studies have shown that short-term intake of high fat foods can cause lipid metabolism disorder, a