Compound Technology javanica oil microemulsion.docVIP

 PAGE \* MERGEFORMAT 11 Compound Technology javanica oil microemulsion [Abstract] [Objective] The oral preparation of compound javanica oil microemulsion. [Method] The solubility experiments and pseudo-ternary phase diagram of the drawing, to form a microemulsion as the index size of the area, screening the oil phase, emulsifier, emulsifier the best match with the prescription javanica oil ratio, the proportion of the best prescription. [Results] The mass ratio of the microemulsion formulation: MCT8%, javanica oil 4%, RH40 21%, 7% ethanol , water 60%. [Conclusion] The preparation of physical and chemical properties of compound javanica oil emulsion stability. [Keywords:] javanica oil; 5-fluorouracil; pseudo-ternary phase diagram Abstract: [Objective] To prepare the compound microemulsion of Brucea javanica oil. [Methods] Through solubility experiments and drawing pseudo ternary phase diagram, optimum size of microemulsion region to determine the proportion of different prescription form, to determine the proportion of different prescription forms . [Results] The microemulsion of the prescription ratio: MCT8%, Brucea javanica oil 4%, RH40 21%, anhydrous ethanol, 7%, water 60%. [Conclusion] The microemulsion has stable physico chemical properties, it could provide a basis for further study. Keywords:: Brucea javanica oil; 5 Fluorouracil; pseudo ternary phase diagram of compound javanica oil emulsion is commonly used anticancer drugs in clinical javanica oil and 5-fluorouracil (5 fluorouracil, 5 FU) combined oral microemulsion made. clinical studies have shown [1], Brucea javanica oil emulsion can be combined with 5 FU to 5 FU with the javanica oil targeted to act on cancer cells, cancer cell infiltration to produce synergistic killing cancer cells, reduce damage to normal cells, while 5 FU javanica oil can reduce the immunosuppressive effects to enhance the body immunity. microemulsion can overcome the short half-life of 5 FU, the shortcomings of poor