Compound with single preparations of anti Comparative Study of Cerebral Ischemia.docVIP

 PAGE \* MERGEFORMAT 14 Compound with single preparations of anti Comparative Study of Cerebral Ischemia Of: Wu Xiao Fei, Jin Cuiying, HU Yu Chi, Zhou Jianping, Hu Jie, Hu Kofi [Abstract] Objective To compare drugs A, B three kinds of drugs and drug S single preparations and compound preparations containing the three drugs through participation in the anti-Dan acute cerebral infarction cerebral ischemia and ischemic reperfusion injury differences. Methods Mice acute cerebral ischemia and ischemic reperfusion (CIR, observation of drug A injection (8.0mg/kg, drugs S injection (33.0mg/kg, Drug B Injection (13.3mg/kg and brain stem through injection Shendan solution (54.3mg/kg survival time of mice, brain water content, brain tissue malondialdehyde (MDA content and superoxide dismutase (SOD, lactate dehydrogenase (LDH and glutathione peroxidase ( GSH-Px activity. Results Compared with the single preparations, the brain stem through Shendan injection prolonged the survival time was markedly increased (P lt;0.05, Shendan injection cerebral infarction through inhibition of MDA content increased and the inhibition of SOD, LDH, GSH-Px activity decreased the effect is more obvious (P lt;0.05. However, in CIR injury induced inhibition of brain water content increased, the single drug group side and the brain stem through Shendan was no significant difference between. Conclusion compound Shendan cerebral infarction pass (54.3mg/kg on acute cerebral ischemia and ischemic reperfusion injury have a protective effect against cerebral ischemia and hypoxia, reduce free radical damage, reduce the inflammatory response are better than the combined effects of Drug A, Drug B S and drug side of three single-agent group. [Keywords:] model of acute cerebral ischemia, ischemic reperfusion model, compound injection Cerebral ischemia, also known as ischemic stroke, cerebral infarction, is a type of blood supply to the brain disorders caused by ischemia, hypoxia, resulting in n