Cordyceps extract combined with dexamethasone inhibited rat corneal neovascularization.docVIP

 PAGE \* MERGEFORMAT 12 Cordyceps extract combined with dexamethasone inhibited rat corneal neovascularization [Abstract] Objective: To observe the Cordyceps Extract (cordyceps militaris extract, CME) and dexamethasone (dexamethasone, Dex) on rat corneal neovascularization. Methods: 48 rats method using alkali burn rat corneal neovascularization model, were randomly divided into 3 groups: A group for the model control group, B group for the CME group, C group CME Joint Dex treatment group. After modeling each group every other day injection, A group were given physiological subconjunctival injection of saline, B group was treated with subconjunctival injection of CME 10mg, C were given CME 10mg subconjunctival injection, the other to give 0.25g / L Dex eye drops, 3 times / d. 4,8,14 d after operation measuring the growth of corneal neovascularization area, and to measure corneal tissue expression of VEGF and its mRNA. RESULTS: After modeling combined group’s area of corneal neovascularization compared with model control group and treatment group was significantly reduced CME, the difference was statistically significant (P lt;0.05. Conclusion: CME Joint Dex inhibited more alkali burn induced corneal neovascularization growth. [Keywords:] Cordyceps Extract, dexamethasone, corneal neovascularization, vascular endothelial growth factor Abstract ?r AIM: To observe the inhibition effect on rat corneal neovascularizition (CNV) by drug combination of the cordyceps militaris extract (CME) and dexamethasone (Dex). METHODS: CNV model was induced by alkaline burn of the cornea with 1mol / L NaOH . Forty eight rats were divided into three groups randomly after modeling, A was model group, B was CME treatment group, and C was combination treatment group. All groups received medication by subconjunctival injection every other day after alkaline burn, group A received saline, group B received 10mg CME, group C also received 10mg CME, and received 0.25g / L Dex eyedro