Crystallization Thermodynamics of cefazolin sodium.docVIP

 PAGE \* MERGEFORMAT 17 Crystallization Thermodynamics of cefazolin sodium Author: Wu Jie Hua Jing-Kang Wang Qiu-Xiang Yin Mei-Jing Zhang Abstract by differential thermal analysis determination of cefazolin sodium thermal decomposition temperature and decomposition; using laser Determination of cefazolin sodium in different ratio of water  ethanol, water  acetone, isopropyl alcohol mixture of water  Solubility data, using exponential model of the solubility data correlation; the final determination of cefazolin sodium in water and mixed solvents of water and isopropyl alcohol in the cooling crystallization of metastable zone data for cefazolin sodium in industrial production provide the basis of thermodynamics. Keywords: cefazolin sodium; crystallization; thermodynamics; Metastable Zone Crystallization thermodynamics of cefazolin sodium pentahydrate ABSTRACT The decomposition temperature and heat of cefazolin sodium pentahydrate were measured by the differential scanning calorimetry technique. Its solubility data in various mixed solvents of water  ethanol, water  acetone, and water  2  propanol were obtained by the laser method and fitted by the exponential model. Finally, the crystallization metastable zone of cefazolin sodium pentahydrate in water and the mixture of water and 2  propanol at different temperatures was determined by the laser method. Valuable thermodynamics data for the industrial manufacture of cefazolin sodium pentahydrate were obtained. KEY WORDS Cefazolin sodium pentahydrate; Crystallization; Thermodynamics; Metastable zone Crystallization process in solution crystals in the Department of physical and chemical properties (such as solubility, melting heat, metastable zone, etc.) on the crystallization operation, crystal yield, product purity and particle size distribution of products have a greater impact, the Department of crystals thermodynamic nature of the crystallization kinetic