Cytokine signal transduction inhibitor 1 (SOCS 1) Research Progress.docVIP

 PAGE \* MERGEFORMAT 24 Cytokine signal transduction inhibitor 1 (SOCS 1) Research Progress Abstract cytokine signal transduction inhibitor (suppressor of cytokine signaling, SOCS) family is a class of cells and the feedback of blocking cytokine signal transduction process, negative regulation factor, first discovered that the SOCS  1. SOCS  1 inhibited IL  6, LIF, OSM, INF  γ, as well as GH and other cytokines signal transduction, in vivo activation of the immune response from a variety of in vitro. Abnormal expression of SOCS  1 with a variety of diseases related to the acute and chronic leukemia, rheumatoid arthritis, cirrhosis and liver cancer may play an important role in the pathogenesis. In this paper, SOCS  1 and the relationship between cytokines and its clinical research are reviewed. Keywords: cytokine signal transduction inhibitor  1; cell factor; high methylation; signal transduction; leukemia Progress of Study on Suppressor of Cytokine Signaling  1 - Review Abstract Suppressor of cytokine signaling (SOCS) is a new family of proteins produced in cells. It may play an important role in classic negative feedback loop to regulate cytokine signal transduction. SOCS  1 was observed and confirmed firstly. Expression of SOCS  1 can inhibit cytokine signal transduction of some cytokines, such as IL  6, LIF, OSM, INF  γ, GH, and so on, many immune responses are regulated by them in vivo. Abnormal expression of SOCS  1 is closely related to some human diseases. It plays an important role in the development of leukemia, rheumatoid arthritis, liver cirrhosis and liver cancer. In this review, the advances of research on the relationship between SOCS  1 and cytokine, and its correlation with some diseases were summarized. Keywords: SOCS; cytokine; hypermethylation; signal transduction; leukemia Cytokine signal transduction inhibitor (suppressor of cytokine signaling, SOCS) family is a class of cells and th