Dan Hong injection with Citicoline Sodium Injection Compatibility of fluid composition on the stability of phenolic acids.docVIP

 PAGE \* MERGEFORMAT 10 Dan Hong injection with Citicoline Sodium Injection Compatibility of fluid composition on the stability of phenolic acids Author: Duxiu Fang Wei-Na Liu Zhang Meilan Liu Min Ying Wu Haiyan [Abstract] Objective To investigate the Danhong injection with Citicoline sodium injection in 0.9% sodium chloride injection in the stability of compatibility. Methods gradient elution RP-HPLC determination of compatibility of liquid Danshensu, protocatechuic aldehyde, Sal B in the 6 h within the content and determine its 24 h at 25 ℃ pH values. The results of the main component of Danshensu, protocatechuic aldehyde and Dan acid content of B had no significant changes; Danhong injection with Citicoline sodium injection within 24 h after the pH compatibility basically stable. Conclusion Danhong injection with Citicoline sodium injection after the pH value and compatibility of Danshensu, protocatechuic aldehyde, Dan B, quality of acid within 6 h was basically stable. [Keywords:] RP-HPLC Danhong injection Danshensu protocatechuic aldehyde Sal B Citicoline sodium injection compatible stability By Salvia, safflower extract solution crafted Danhong injection, the active ingredients are mainly water-soluble phenolic constituents Danshensu, protocatechuic aldehyde, Sal B and so on, can inhibit platelet aggregation, anti-thrombosis, anti-oxidation and the protection of cardiac microvascular endothelial cells [1] and so the role of the clinical primarily for the treatment of cardio-cerebral vascular disease. Dan Hong injection drug compatibility with other applications can not yet see the relevant literature. In this study, the concentration of simulated clinical use of drugs, study Danhong injection at 25 ℃ with Citicoline sodium injection in 0.9% sodium chloride injection after the pH and the appearance and compatibility of Danshensu, protocatechuic aldehyde, Sal B, content changes, provide a reference for clinical medicine [2,3]. An instrument and reage