DBifidobacterium supernatants on anti-aging effect of galactose.docVIP

 PAGE \* MERGEFORMAT 8 DBifidobacterium supernatants on anti-aging effect of galactose [Abstract] Objective To observe the Bifidobacterium supernatants (SCS) of D galactose induced subacute aging mice lipids and learning and memory, and to explore the mechanism of lowering blood lipids SCS, SCS for further study of effective anti-aging component provides a theoretical basis. Methods Mice D galactose neck subcutaneous injection and saline build subacute aging model and normal control. Meanwhile, the experimental group of mice were injected intraperitoneally SCS, continuous culture after 42 d weight, total serum cholesterol (TC), triglyceride (TG) and high density lipoprotein (HDL C) content. Results Compared with model group, the experimental group, serum TG, TC level decreased significantly (P lt;0.05), serum levels of HDL C significantly improved learning and memory were significantly improved compared with the model. Conclusion SCS can reduce serum TG, TC content, D galactose delay the aging process in mice. [Keywords:] Bifidobacterium supernatants; D galactose; aging; lipid; learning and memory Bifidobacterium supernatants (spent culture supernatant, SCS) metabolites mainly composed of bifidobacteria, including the metabolism of organic acids, bacteriocin and the cell itself, the structure of material, mainly composed of protein and polysaccharide. ZHOU Zheng-Ren et al ( 1) organic solvent precipitation collected by cell polysaccharide (EPS), and in vitro intestinal epithelial cells and lymphocytes (iIEL) were incubated iIEL found on immune activation. Many scholars have proposed the existence of SCS bacteriocin, adhesin and other active ingredients (2 to 4), immune regulation, sterilization, anti-aging and other biological effects. The SCS through observation of D galactose induced subacute blood of aging mice, of SCS mechanism for lowering blood lipids. 1 Materials and methods 1.1 Animals Male Kunming strain mice, rats aged 3 months, body we