DChinese Han male population amino acid oxidase activator gene polymorphism and schizophrenia research.docVIP

 PAGE \* MERGEFORMAT 12 DChinese Han male population amino acid oxidase activator gene polymorphism and schizophrenia research Of: Han Yan, Ning Qilan, Zhang Huan, WANG Shu, Zhang Fujun, Ma Xuehong, high into the Court, Ma Jie [Abstract] Objective To study the male population in the D amino acid oxidase activator (DAOA) gene polymorphism associated with schizophrenia. Methods of PCR, allele characteristics of 272 patients with schizophrenia and 206 male controls were DAOA gene region of 3 single nucleotide polymorphisms (SNP: rs778294, rs778293 and rs3918342) were genotyped, and statistical analysis. Results DAOA gene region rs778294 A allele (C) with schizophrenia were significantly correlation (P = 0.03). constructed by a three SNP haplotype analysis showed that the haplotypes in case-control group CAT show significant differences. Conclusions men in the Chinese Han population, DAOA gene might be schizophrenia a susceptibility gene, NMDA receptor pathway may occur as an important potential factor in schizophrenia. [Keywords:] Schizophrenia; D amino acid oxidase activator; single nucleotide polymorphism; linkage disequilibrium; association ABSTRACT: Objective To examine the correlation betweenD aminoacid oxidase activator (DAOA) gene polymorphisms and schizophrenia in the Han Chinese males.Methods We genotyped three single nucleotide polymorphisms (rs778294, rs778293 and rs3918342) in DAOA gene region in 272 male patients with schizophrenia and 206 controls using allele specific real time PCR. Results Significant association between the C allele of marker rs778294 and schizophrenia was found (P = 0.03). Furthermore, the analysis by multiple haplotype constructed with three SNPs revealed a strongly significant difference for the common haplotype CAT between case and control groups.Conclusion DAOA gene may be a candidate susceptibility gene for schizophrenia in the Han Chinese males, and the NMDA receptor pathway may play a potential important role i