Dendritic cells and immune regulation of Progress.docVIP

 PAGE \* MERGEFORMAT 14 Dendritic cells and immune regulation of Progress [Keywords:] dendritic cell; autoimmune disease; immune tolerance 1973, Steiman and Cohn [1] for the first time isolated from the spleen of a class with granulocytes, macrophages and lymphocytes in morphology and function of white blood cells are different, because the membrane outwards, similar to the formation of axons and nerve cells membrane of the tree processes, hence the name dendritic cells (dendritic cells, DCs). DCs subsequent study found that the first link in the immune response - antigen presentation plays an important role, is widely recognized as the body’s most powerful professional antigen presenting cells (antigen - presenting cell, APC). It can activate resting T cell type mainly involved in cellular immunity and T cell dependent humoral immune response, in the maintenance of the body’s own immune tolerance and activation of peripheral T , B lymphocytes play an important role, and inflammation, autoimmune diseases, transplantation immunology and cancer therapy are closely related. 1 DCs biological characteristics DCs is a typical dendritic morphology, membrane surface expression of MHC-I class and MHC- molecules, can migrate to lymphoid organs to stimulate resting T cells activated type, and has some relatively specific surface marker of a type cells. 1.1 DCs and distribution of the source DCs derived from bone marrow CD34 + cells were few in number, accounting for only less than 1% of peripheral blood, spleen cells accounted for 0.2% ~ 0.5% [2]. DCs precursor cells from bone marrow into the peripheral blood, and then distributed to the whole body The organization noted in its migration in different parts of different names: (1) follicular dendritic cells (Follicular dendritic cell, FDC: the dendritic effectively capture the complex forms of antigen, and will long remain in the surface antigen, secondary follicles to maintain memory function, but also w