Detection of mitochondrial damage and Progress.docVIP

 PAGE \* MERGEFORMAT 14 Detection of mitochondrial damage and Progress Of: the money left to fly, Zhang Xian, Lu Pengfei Abstract: Mitochondria are the cellular “energy factories”, the role of various risk factors prone to a variety of mitochondrial structure and function of damage, which the development of the disease plays a very important effect on mitochondrial structure and function of the article Damage detection methods are reviewed. Keywords: Mitochondria; mtDNA; apoptosis Abstract: Mitochondria are cell activities of the “energy factories”, in a variety of pathogenic factors appear vulnerable to a variety of mitochondrial structure and function of injury, which in the development of the disease plays an important role. This article on the structure and function of mitochondrial damage and its detection methods are reviewed. Keywords:: mitochondrial injury mtDNAApoptosis Mitochondria in biological growth, development, metabolism, aging, disease, death and other aspects of biological evolution is significant, and the role of various risk factors prone to a variety of mitochondrial structure and function of damage. Withered in the cell death process, endogenous endonuclease, Caspase family proteases, signal transduction, apoptosis-related genes, oxygen free radicals, Ca2 +, NO, energy metabolism, mitochondria are involved in the occurrence of mitochondrial apoptosis and apoptosis there is a close relationship between this development of the disease plays a very important influence, and therefore the detection of mitochondrial damage is also very crucial significance. 1mtDNA Damage and Repair 1.1ROS oxidative damage of mtDNA Maintain the cells of human mtDNA encoded electron transport chain and ATP generation, and physiological activity of 13 essential polypeptides, 22 transfer RNA (tRNA) and 2 ribosomal RNA (rRNA). MtDNA suffer oxidative stress, will result in uncoupling protein 2 (UCP - 2) gene, the potential dep