Dioxin on the impact of learning and memory in mice.docVIP

 PAGE \* MERGEFORMAT 10 Dioxin on the impact of learning and memory in mice [Abstract] Objective: To study the dioxin (TCDD) for the impact of learning and memory in mice. Methods: 48 male and female Kunming mice were divided into sex-high, medium and low-dose group and the control groups of 6 rats exposed to doses of 100 g / kg body weight, 10 g / kg body weight, 1 g / kg body weight, intraperitoneal injections with exposure time, 24 h and 48 h after the step down test, record mice jumped the first jump of the latency and the number of errors. Results: Compared with the control group, the high dose group of male mice significantly increased the memory latency (P lt;0.05), in the memory experiment, female mice with low , high dose group of mice the number of errors jumped out of the platform significantly increased (P lt;0.05). Conclusion: dioxin on learning and memory function in mice has some influence, and gender differences. [Keywords:] dioxin; learning and memory; step down test Abstract Objectives: To assess the effect of TCDD on the learning and memorial function of mice. Methods: 24 male mice and 24 female mice were randomly divided into four groups according to the sex: high dose (100 g / kg) grop, middle dose (10 k / kg) group, low dose (1 g / kg) group and the control group. Each group has 6 mice. The mice were injected ip with TCDD (controls were injected ip with DMSO). After 24 hours and 48 hours , the step-down test was performed to evaluate the learning and memorial function of the mice. Results: Compared with the controls, there was a significant increase in the memorial latent time of the male mice (P lt;0.05) from the high-dose group and the wrong step down times was significantly increased in the female rats with low and high dose of TCDD (P lt;0.05). Conclusions: TCDD has certain effects on the learning and memorial function of mice, with some differences between male and female mice . Keywords: 2,3,7,8-tetrachlorodibenzo-p-dioxi