Dosing of the fluid particles of insoluble.docVIP

 PAGE \* MERGEFORMAT 12 Dosing of the fluid particles of insoluble Author: Xu Xue-Jun Xu Deqin Wang Ying Zou Ruofei 【Key Words】 infusion;,, small volume injection;,, insoluble particles,,,,, Abstract: Objective: To investigate the small volume injection of agents and dosing environment on the impact of transfusion of insoluble particles. Methods: Injection cefradine other five kinds of sterile powder injection and dexamethasone sodium phosphate injection and other five kinds of small volume injection, respectively, and purification treatment rooms in the ward clean room, routine operation, the sterile powder injection, respectively, adding 0.9% sodium chloride injection, the injection of small volume, respectively in 5% glucose injection in order to photoresist Determination of insoluble particles in the sample. Results: Compared with no pre-infusion dosing compared to adding a small volume injection, the ward treatment room and purification of the samples prepared clean room, ≥ 10μm insoluble particles were increased significantly (P lt;0.05), ≥ 25μm particles are insoluble no significant increase (Pgt; 0.05); ward treatment room sample preparation and purification of the samples prepared by relatively clean room, ≥ 10μm insoluble particles increased very significant (P lt;0.01), ≥ 25μm no significant increase of insoluble particles (Pgt; 0.05 ). Conclusion: Add small volume injection of non-cleaning agents and dosing in ward treatment rooms will enable the transfusion of ≥ 10μm insoluble particles increased significantly. Keywords: infusion; small volume injection; insoluble particles Infusion, and other injection of insoluble particles into the blood, may cause vascular thrombosis, allergic reactions, heat as is the reaction of [1]. 1985 edition of “The People’s Republic of China Pharmacopoeia”, starting a large volume injection of insoluble particulate limits there are specific provisions in 2005 edition of “The People’s Republi