Dose escalation of topiramate in the treatment of refractory epilepsy clinical observation.docVIP

 PAGE \* MERGEFORMAT 9 Dose escalation of topiramate in the treatment of refractory epilepsy clinical observation [Abstract] Objective To observe the dose escalation of topiramate in the treatment of refractory epilepsy and adverse effects. Methods 16 to 63 years of age, duration of 2 to 28 years in 42 patients with refractory epilepsy patients, no change in the original first-line antiepileptic drug the case of addition of topiramate therapy. for each patient observed for at least 5 months, based on 1 month, plus the amount of 1 month, stable for 3 months. plus the amount of ways, starting with topiramate 50 mg / d , after the weekly increase in 50 mg / d, increased to 4 weeks to 200 mg / d until the target dose. statistical stability of the 3-month average monthly seizure frequency and dose escalation of topiramate treatment the average monthly number of attacks, and for therapeutic evaluation. Results duly adjunctive treatment of refractory epilepsy total effective rate was 76.2%, of which simple partial seizures and 87.5%, complex partial seizures 72.7% efficient, effective systemic seizures 73.9%, adverse reactions light. Conclusion properly adjunctive treatment of refractory epilepsy and effective, safe and well tolerated and is worthy of promotion. [Keywords:] topiramate, dose escalation, refractory epilepsy Epilepsy is a common chronic disease of the nervous system, the traditional antiepileptic drugs (AEDs formal system of treatment, most patients seizures may be controlled, but there are still 20% to 30% of patients with ineffective therapy [1]. Topamax (Topiramate, TPM is a new antiepileptic drug, with the treatment of intractable epilepsy have a positive effect [2, 3]. our department in January 2004 to May 2008 with increasing doses of topiramate in the treatment of refractory Epilepsy self-controlled study to evaluate efficacy and adverse reactions, are as follows. Materials and Methods 1. Selected Case Standard diagnostic criter