Doxycycline on carotid atherosclerosis of.docVIP

 PAGE \* MERGEFORMAT 12 Doxycycline on carotid atherosclerosis of Of: Guo Yuan Xin, Luo Junsheng, Guan Ning, Huo Xiaochuan, Li Huiwen [Abstract] Objective To observe doxycycline on carotid atherosclerosis and the formation of atherosclerotic vessel wall related proteins, expectations for the formation of carotid atherosclerosis provide new clues to prevention and treatment. Methods intragastric balloon injury combined with high fat diet plus intraperitoneal injection method VD rat model of carotid artery atherosclerosis, given doxycycline, observe its effect on atherosclerosis formation and MMP-2, MMP-9 expression. Results MMP-2, MMP-9 in atherosclerotic model was highly expressed in the vascular wall, can decrease the expression of matrix metalloproteinases. Conclusions The expression of matrix metalloproteinases with the formation of atherosclerosis is closely related to inhibition of its expression could inhibit atherosclerosis atherosclerosis formation. [Keywords:] atherosclerosis, doxycycline, matrix metalloproteinase Abstract: Objective To explore the effect of doxycycline on the formation of AS and the expression of AS relative proteins, with the expection to find a new prophylaxis and therapy clue to the formation of carotid Atherosclerosis. Methods To establish Carotid atherosclerotic rat model by using vitamin D and fat diet after balloon injury. Doxycycline was applied, observing its influence on the formation of atherosclerosis and the expression of MMPs. Results Doxycycline could inhibit MMPs expression in carotid artery wall of AS. Conclusions MMP-2 and MMP-9 were in close relationship with the formation of AS. Non-specific down-regulation of MMPs expression could inhibit the formation of AS. Keywords:: atherosclerosis (AS); doxycycline; matrix metalloproteinase (MMP) Carotid atherosclerosis prevention is the field of neurological surgery hot topic. Recent studies suggest that, MMPs activity increased, or the formation of extrace