Doxycycline rabbit model of braking the treatment of osteoarthritis.docVIP

 PAGE \* MERGEFORMAT 11 Doxycycline rabbit model of braking the treatment of osteoarthritis [Abstract] [Objective] doxycycline on the rabbit model of braking the treatment of osteoarthritis and its mechanism. [Method] 24 New Zealand white rabbits were randomly divided into normal, model, control and treatment group, n = 6 only. In addition to the normal group, all animals in the left lower limb cast immobilization for 4 weeks in the extension position. and then the treatment group were given oral doxycycline treatment, 4 weeks after the degeneration of the medial femoral condyle, and to detect collagen type Ⅱ , urokinase-type plasminogen activator (urokinase type plasminogen activator, uPA and matrix metalloproteinase (matrix metallo proteinase, MMP-13 level. [Results] The model of cartilage degeneration and the control group was significantly more reduced model and the control type Ⅱ collagen content between groups, uPA and MMP-13 expression was not statistically significant (Pgt; 0. 05, other groups were statistically significant difference (P lt;0. 01.uPA and MMP-13 expression was positive correlation (r = 0. 973, P lt;0. 05. [Conclusion] doxycycline inhibit cartilage degeneration and improve cartilage structure. its role and uPA, MMP-13 expression inhibition. [Keywords:] osteoarthritis, doxycycline, urokinase-type plasminogen activator, matrix metalloproteinase Abstract: [Objective] To investigate the effects of doxycycline on rabbit immobilized osteoarthritis and their mechanism. [Method] Twenty four rabbits were randomly divided into normal, model, control and treatment groups, with 6 rabbits in each group.All of the animals were immobilized the lower left limbs with plaster bandage for 4 weeks except normal group.Doxycycline was orally given to treatment group.Cartilage degeneration of the medial condyle of femur was observed at 4 weeks and the levels of collagen Ⅱ, uPA and MMP 13 were tested. [Result] Cartilage degeneration in treatment group w