Drug-induced hepatitis and clinical analysis of 76 cases.docVIP

 PAGE \* MERGEFORMAT 5 Drug-induced hepatitis and clinical analysis of 76 cases [Keywords:] drug-induced hepatitis; pathogenesis In recent years, with the clinical application of drug types increased, the incidence of drug-induced hepatitis is also increased. Now nearly five years, our hospital, 76 patients with drug-induced hepatitis and clinical analysis of the causes and increase their understanding. Clinical data 1. General information our hospital 76 cases of drug-induced hepatitis, 32 patients were male, female 44 cases, aged 13 to 65 years (mean 38.2 + -14.1 years). 2. Premorbid diagnosis 1 ~ 2 weeks or more for a long time have a clear medical history. were fatigue, anorexia, vomiting, upper abdominal distension and discomfort, skin yellow, dark urine, yellow eyes, rash, skin itching and other liver substantial cell damage or clinical manifestation of intrahepatic cholestasis. exclude A-G hepatitis, EB virus, cytomegalovirus, herpes simplex virus infection in the toxic hepatitis, autoimmune hepatitis, genetic liver disease, alcoholic liver disease, some Based on the combined liver disease, but taking normal hepatic function. clinical test: significantly higher than normal transaminase 2 times, serum bilirubin greater than 34.7 mmol / L. 3. Drug types in this group are more types of drugs damage the liver, the herbal medicine, Chinese medicine, such as impotence kidney capsule, detoxifies capsule, elimination of nuclear piece, fleece-flower root, Dioscorea bulbifera, fish guts, herbs and other ingredients of unknown 27 cases, accounting for 35.5%; anti-TB drugs in 23 cases, 30.3%; agents, antibiotics, all 6 cases, accounting for 7.89%; anti-inflammatory drugs in 5 cases, 6.57%; antipsychotic drugs, lipid-lowering drugs, hypoglycemic The 3 drugs, which accounted for 3.95%. 4. Treatment results of a drug-induced hepatitis 76 cases confirmed by liver damage should stop all medication, bed rest, drink plenty of vitamins, to nourish t