Dragons Blood Dragons Blood Dragon Blood-A and-B in rats in vivo tissue distribution study of.docVIP

 PAGE \* MERGEFORMAT 9 Dragon’s Blood Dragon’s Blood Dragon Blood-A and-B in rats in vivo tissue distribution study of Author: Sun Xiaobo, gold painted true, Li Xue, Jin-Ge [Keywords:] Dragon’s Blood; Loureirin A; Loureirin B; high-performance liquid chromatography; tissue distribution Abstract: Objective To study the tissue distribution of loureirin A and loureirin B in rats.Methods After intragastric (ig) administration of loureirin A and loureirin B at doses of 250 mg/100 g in rats, the tissue concentrations at different time points were determined by HPLC. Results After ig administration, the main tissue distributions of loureirin A and loureirin B in rats were similar. The loureirin A and loureirin B concentrations in the liver and kidney were the highest and those in the spleen, heart, lung, brain, and muscle decreased sequentially. Conclusion There was an extensive distribution of loureirin A and loureirin B in rats. Keywords:: Dracaena cochinchinensis (Lour) SCChen; loureirin A; loureirin B; HPLC; tissue distribution; Dragon’s blood (Dragon’s blood), also known as Kirin have dried up, for the traditional precious Chinese medicine. Chinese-made Dragon’s Blood Dragon’s blood, said, Dragon’s Blood with blood circulation, stasis, stop bleeding, the efficacy of blood, known as ‘blood circulation St drugs’ [1], clinical application of a wide range. Dragon’s Blood reported in the literature the main ingredients of flavonoids, which in the treatment of coronary heart disease, cerebral infarction, myocardial ischemia, cerebral ischemia injury in such areas make a significant effect [2,3]. Loureirin A, Dragon’s Blood Dragon’s Blood-B is the main component of flavonoids, so this paper, HPLC method [4] determined the dragon and the dragon of blood-A blood-B concentrations in different tissues, provide a theoretical basis for clinical application . 1 Materials and methods 1.1 Animals SD rats, body weight (250 ± 20) g, both male and female, from the Animal C