Effect of melatonin on A-induced brain expression of GFAP and S100 protein in the intervention.docVIP

 PAGE \* MERGEFORMAT 13 Effect of melatonin on A-induced brain expression of GFAP and S100 protein in the intervention Of: Chen Kun Zhou Li Zhou Jun Song and Zeng Qingren shun Tin Yee [Abstract] Objective To investigate the melatonin (MT) intervention -amyloid (A)-induced rat brain glial fibrillary acid protein (GFAP) and S100 protein expression of MT on Alzheimer’s disease (AD) treatment mechanism. Methods 30 rats were randomly divided into saline control group, amyloid (A) induced by AD Model group (model group) and the AD model + MT group (MT group). 40 d when the animals get fed rat brain, using HE staining pathological changes in brain tissue, immunohistochemical staining of brain tissues labeled A and A toxicity on neurons, glial cells, simultaneous detection of GFAP and S100 protein levels. Results HE staining brain lesions in MT was significantly lighter than the model group; Immunohistochemistry showed that, A expression level of MT in the model group and no significant difference between the two groups, but the A on hippocampal CA3 neurons in the model damage group is greater than the MT group. GFAP and S100 expression in model group were significantly higher than the MT group and normal group (P lt;0.05). Conclusion MT intervention can reduce the expression of glial cells in AD model rats GFAP and S100 protein level, which play a large neuronal cells to reduce injury. [Keywords:] melatonin; dementia; amyloid protein; astrocytes Alzheimer’s disease (AD) is a common Alzheimer’s disease, mainly as the loss of cognitive and structural damage neuropathic, including brain atrophy, senile plaques and neurofibrillary tangles with a large number of -amyloid (A ) deposition. AD is life threatening health and old age groups, one of the diseases most important (one), there is no effective treatment, so depth study of AD pathogenesis and to find effective treatment is important. studies have shown that aging and brain A deposition is the main reaso