Elderly diffuse large B-cell lymphoma effect of combination chemotherapy.docVIP

 PAGE \* MERGEFORMAT 11 Elderly diffuse large B-cell lymphoma effect of combination chemotherapy [Abstract] Objective To evaluate the elderly diffuse large B cell lymphoma with rituximab in combination with chemotherapy in the treatment efficacy and adverse reactions. Method observed for 12 elderly patients (older than 65 years with diffuse large B cell lymphoma with rituximab in combination with chemotherapy in the treatment of the condition, respectively 2-8 R-CHOP in the treatment regimen, followed by the single-agent rituximab maintenance (once every 3 months, the longest for 2 years of rituximab in combination with chemotherapy efficacy and toxicity. Results 12 patients reached complete remission (CR, no serious adverse reactions. Conclusions of rituximab combined with chemotherapy in treating senile large B cell non-Hodgkin’s lymphoma can enhance the effectiveness, does not increase toxicity, to improve the CR rate and remission DLBCL survival, drug resistance good. [Keywords:] elderly diffuse large B cell lymphoma, rituximab in combination with chemotherapy Diffuse large B cell lymphoma (DLBCL is a group of the most common source of B lymphocytes, and has a heterogeneous non-Hodgkin’s lymphoma. Diffuse large B cell lymphoma (DLBCL accounted for 40% of B-cell lymphoma , accounting for 30 adult NHL, 40%, non-Hodgkin’s lymphoma (NHL largest subtype is the most common types of Chinese patients. elderly diffuse large B cell lymphoma (DLBCL is not uncommon, more than 60% of patients B-cell lymphoma was diagnosed at the age of 60 years of age are. monoclonal antibody rituximab (Mabthera, rituximab, IDEC-C2B8 initial chemotherapy for the treatment of relapsed or resistant to low or follicular non-Hodgkin lymphoma ( non-hodgkin’s lymphoma, NHL, in recent years confirmed that rituximab for aggressive lymphoma has a significant effect. Foreign studies have shown that rituximab in combination with CHOP program can be used as initial treatment of diffuse