Effects of valsartan on ambulatory peritoneal dialysis elderly patients with brain natriuretic peptide and cardiac function.docVIP

 PAGE \* MERGEFORMAT 10 Effects of valsartan on ambulatory peritoneal dialysis elderly patients with brain natriuretic peptide and cardiac function Of: Chen Hui Zhu Qing Shaofeng Min Chen Cheng Silver [Abstract] valsartan Objective older peritoneal dialysis patients before and after treatment of brain natriuretic peptide (BNP) of the change and the impact on heart function. Methods of maintenance peritoneal dialysis in elderly patients 56 patients, according to residual renal function (RRF) level is divided into glomerular filtration rate (GFR)gt; 2 ml / min group (A group) and GFR lt;2 ml / min group (B group), while 23 patients choose healthy control group, peritoneal dialysis patients were given valsartan a dose 80 ~ 160 mg / d, treatment for 3 months. sandwich double antibody immunofluorescence method before and after treatment in patients with BNP, creatinine (Cr), blood urea nitrogen (BUN), serum albumin (ALB) and other content, while patients with color ultrasonic measurement of left ventricular end diastolic diameter (LVEDd), left ventricle ejection fraction (LVEF) and left ventricular mass index (LVMI), and correlation. Results matter in peritoneal dialysis patients aged residual renal function of the level of , BNP were higher (P lt;0.01), but the BNP levels were significantly higher than that of B group A group, the two are different (P lt;0.01), color Doppler ultrasound results of group B patients LVEDd, LVMI was significantly higher than the A group and the control group, LVEF was lower than A group and the control group. peritoneal dialysis after valsartan treatment group were either A or B group, BNP levels and LVEDd, LVMI had decreased, and LVEF increased, compared with the control group significant difference, BNP and LVEDd, LVMI was positively correlated, negatively correlated with LVEF. Conclusion BNP reflect the functional status of dialysis patients, a heart sensitive indicator, RFF the higher heart function better, valsartan signific