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Effect of homocysteine on endothelial cells in rats tPA
PAGE \* MERGEFORMAT 7
Effect of homocysteine on endothelial cells in rats tPA
[Abstract] Objective To investigate the homocysteine #8203;#8203;(Hcy on human umbilical vein endothelial cells (HUVEC tissue-type plasminogen activator (tPA antigen content. Methods Cultured HUVEC were divided into five experimental groups 0 10,50,200,500 mol / L Hcy concentrations of Hcy group and the above-mentioned co-culture group, after 24h culture, enzyme-linked immunosorbent assay method (ELISA measured in the supernatant of each group tPA antigen content. Results Compared with the medium group (0mol / L Hcy compared, 10mol / L Hcy group (physiological tPA concentrations were significantly increased (P lt;0.05. super physiological dose when Hcy, tPA concentration dependently decreased, but there was no significant difference (P lt; 0.05. Compared with the physiological concentrations of Hcy, Hcy concentration when 500mol / L time, tPA antigen synthesis was significantly reduced (P lt;0.05. adding folic acid, reduced Hcy can inhibit the synthesis of tPA antigen, 500mol / L Hcy co-culture group compared with the simple difference between Hcy significantly (P lt;0.05. Conclusion of high Hcy can reduce the secretion of endothelial cell tPA antigen, may reduce the activity of fibrinolytic system. physiological concentrations of Hcy can increase the secretion of endothelial cell tPA antigen, may increase fibrinolytic activity.
[Keywords:] homocysteine, tissue plasminogen activator, human umbilical vein endothelial cells
Homocysteine #8203;#8203;(Hcy is the methionine metabolism in the human body is an important intermediate, high cystine hyperlipidemia (HHE and atherosclerosis and related cardiovascular and cerebrovascular diseases, however, the pathogenesis of HHE is not entirely clear . In this study, the author of the Hcy on human umbilical vein endothelial cells (HUVEC of tPA antigen secretion.
1 Materials and Methods
1.1 General Information Hcy, Sigma, tPA ELISA
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