Elderly patients with acute leukemia and immune gene expression in MLL and prognosis of the clinical significance of abnormal.docVIP

 PAGE \* MERGEFORMAT 15 Elderly patients with acute leukemia and immune gene expression in MLL and prognosis of the clinical significance of abnormal Of: Zhao Junfeng Wang Lixin Cai Yanxia room Sheng-chun Zhang Xiu Long [Abstract] Objective To detect elderly patients with acute leukemia mixed lineage leukemia (MLL) gene expression, and transcripts were part of the dynamic testing, in order to observe gene expression after treatment the changes and to detect its abnormal expression rate and compare the immune treatment and nested PCR results and the results of the sensitivity comparison. way real-time fluorescence quantitative PCR (RQ PCR) detection of MLL fusion gene, MLL leukemia gene expression observed level of MLL gene rearrangement frequency of phenotypic abnormalities and immune cases, chemotherapy. control the expression of MLL gene abnormalities and immune abnormalities of clinical significance. Results of 41 cases of leukemia in the elderly MLL gene was detected in 7 cases, the rate was 17.07%, which MLL AF6 4 cases (24.5%); remission in 4 cases , the MLL gene were lower than the median average. immunological abnormalities in the MLL gene expression detection rate than those without the high frequency of MLL rearrangements, was 28.8%, incidence rate than those without MLL gene rearrangements is high, and remission rate. gene rearrangements and expression and response rates related to anomalies. Conclusion RQ PCR monitoring of fusion gene expression can be effectively observed treatment effect, high sensitivity, MLL leukemia gene rearrangement and molecular mechanisms. Second immune abnormalities in patients with MLL gene expression re- ranked relatively high detection rate, the poor clinical response and efficacy, may indicate a poor prognosis. [Keywords:] Acute leukemia; MLL gene; immune abnormal expression Elderly patients with acute leukemia is common in the elderly because of hematopoietic stem / progenitor cells in the differentiation