Elsinochrome A Study of acute toxicity.docVIP

 PAGE \* MERGEFORMAT 9 Elsinochrome A Study of acute toxicity Author: Jian Zhang Jie on behalf of Wei Guo Jinbao [Abstract] Objective To study the elsinochrome A, acute toxicity, provide a reference for clinical safety of drugs. Methods elsinochrome A high concentration of liquid oral gavage, 1 times / d, continuous observation of 14 d, records of toxicity in mice. The results observed 14 d later, all experimental animals, Jian-Cun, no toxicity. Calculated elsinochrome A dose volume of 5.07 mg / kg body weight, a considerable amount of adults on medication 253 times elsinochrome A maximum tolerated dose of 5 mg / kg body weight. Conclusion elsinochrome A lower toxicity and clinical use of safety. [Keywords:] elsinochrome A; acute toxicity; maximum tolerated dose Abstract: ObjectiveTo study the acute toxicity of Elsinochrome A in mice and to provide some data for its clinical use. MethodsThe high dosage of Elsinochrome A was determined by ig administration in mice once a day. Its acute toxic reactions were observed for 14 days.ResultsAll mice were survive, no toxicity reactions were shown during the observed period. The administration dosage was 5.07 mg of puerarin given to mice per kilogram, equivalent to men’s daily administration dosage by 253 times. The maximum tolerance dose (MTD) of Elsinochrome A was 5 mg of puerarin given to mice per kilogram. ConclusionThe toxicity of Elsinochrome A is low, and the drug is safe and can be used in clinic. Keywords:: Elsinochrome A; Acute toxicity; Maximum tolerated dose (MTD) North quinones photosensitive compounds, first discovered the elsinochrome A (Elsinochrome A, referred to as EA). 1957, Weiss et al [1] of this compound was first isolated in 1969 Ch.Lousberg etc. [2,3] In the spectra determined on the basis of the structure of the EA and its subsequent no more coverage. 1998 Cong Li, Yunnan University (1991 PhD thesis), and Kun, etc. [4] from the mountains of western Yunnan screened a secondary metabolite qui