Endostatin and its anti-angiogenesis effect.docVIP

 PAGE \* MERGEFORMAT 3 Endostatin and its anti-angiogenesis effect [Keywords:] Endostatin category;, neovascularization, pathologic;, tumor Endostatin as an endogenous anti-angiogenic substances, specifically acting on vascular endothelial cells, especially in microvascular endothelial cells, inhibit their migration and induce apoptosis, so as to achieve inhibition of angiogenesis [12]. Because vascular endothelial cells is relatively stable and difficult to generate resistance, and therefore endostatin in tumor angiogenesis has broad application prospects. In this paper, anti-angiogenic effect of endostatin related issues were reviewed. A structure and biological activity of endostatin 1.1 Structure of Endogenous endostatin from 184 amino acids is the perivascular basement membrane collagen Ⅹ Ⅷ parts of the carboxy-terminal fragment of an enzyme [34]; relative molecular mass of approximately 20 kD, crystal structure of spherical, from 7 β folding and next to the two α -helix and a loop formation; sphere surface, rich in arginine, a high degree of affinity for heparin. Its close to the N-terminal there is a Zn2 binding sites, histidine and aspartic acid from the composition of the early studies suggest that Zn2 may be linked to activity of endostatin [5]. However, there are recent studies suggest that, Zn2 is only involved in the structural composition of endostatin, but has nothing to do with its anti-angiogenic effect [67], that is, Zn2 endostatin by influencing the specific conformation to affect their play to a specific biological functions. 1.2 Although the biological activity of endostatin precise and specific biological activity awaits further study, but the broad findings in recent years, at present the biological activity of endostatin or less reflected in the following areas: 1.2.1 on vascular endothelial cell proliferation such as observed selective inhibition of O’Reilly endostatin on bovine aortic smooth muscle cells, rat tumor vascular en