Endothelin NO and TNF in the pathogenesis of diabetic cardiomyopathy in the role of.docVIP

 PAGE \* MERGEFORMAT 11 Endothelin NO and TNF in the pathogenesis of diabetic cardiomyopathy in the role of [Abstract] Objective: To investigate the plasma endothelin, nitric oxide (NO), tumor necrosis factor-@ (TNF @) in the early pathogenesis of diabetic cardiomyopathy in the role. Methods: 57 patients with type 2 diabetes, according to echocardiography Figure Results Patients were divided into DM group (DM group and the group of diabetic cardiomyopathy (DC group, and the other 30 patients selected as healthy control group (NC group. endothelin were measured in all patients, NO and TNF @ level. Results : Compared with the NC group, DC group of patients with E / A ratio decreased, left atrial diameter (LAD increased and so the performance of left ventricular diastolic dysfunction. DC plasma endothelin in patients, NO levels were significantly higher and TNF @ NC group and the DM group (P lt;0.01). Linear correlation analysis showed that plasma endothelin, NO, TNF @ levels and ejection fraction (EF, E / A showed a negative correlation. Conclusion: Left ventricular diastolic dysfunction in diabetic cardiomyopathy early manifestation of the disease, endothelin, NO and the abnormal expression levels of TNF @ in the early occurrence of diabetic cardiomyopathy, accounting for the development of a very important position. [Keywords:] diabetic cardiomyopathy, nitrous oxide, endothelin, tumor necrosis factor-@, left ventricular diastolic function [Abstract] Objective: To explore the role of endothelin, nitric oxide (NO) and tumor necrosis factor @ (TNF @) in the pathogenesis of early diabetic cardiomyopathy.Methods: According to the results of color Doppler ultrasonic cardiogram, 57 cases of type 2 diabetes mellitus were divided into 2 groups: diabetes mellitus group (DM group) and diabetic cardiomyopathy group (DC group), 30 cases of healthy people were chosed as normal control group (NC group). The level of blood endothelin, NO and TNF @ were detected, respectl