Endothelial progenitor cell dysfunction and diabetic retinopathy related research.docVIP

 PAGE \* MERGEFORMAT 18 Endothelial progenitor cell dysfunction and diabetic retinopathy related research Of: E Song Yang Wei Shi Hui Cui Zhihua [Keywords:] diabetic retinopathy, dysfunction of endothelial progenitor cells Of diabetic retinopathy (DR) is the major microvascular complications of retinopathy clinical, epidemiological survey, the community diabetes population the prevalence of DR of up to 27.3% (1), DR has become an adult in the eyes of the blind the first disease. retinal neovascularization is the final blinding DR The main reason for the formation of new blood vessels DR mechanism to prevent its occurrence and development has become the forefront of ophthalmic research and focus. Recent studies Table Mingneipizu cells (EPCs involved in the physiological and pathological conditions, retinal neovascularization process and play an important role, diabetes (DM dysfunction of EPCs in patients with DR may progress and pathological neovascularization are closely related, and to some extent determine the severity of DR. This paper studies the nearest years are reviewed. 1 EPCs biological characteristics In 1997 Asahara (2) and so for the first time were isolated from adult peripheral blood EPCs, and prove not only the existence of angiogenesis after birth, there is also dependent on EPCs in angiogenesis, mainly from further study showed that EPCs marrow, cord blood, peripheral blood and embryonic stem cells. EPCs with colony-forming stem cells in cloning feature, both production of nitric oxide (NO), phagocytosis of acetylated low density lipoprotein (acetylated low density lipoprotein, ac LDL) and the opposite sex and Nei Pite lectin (lectin) binding capacity. EPCs not by single cells, but a class contains a different differentiation state of endothelial precursor cell population, thus far, EPCs still lack a unified surface markers. is generally believed that according to the source, morphology, proliferation capacity, differentiation