Esmolol on coronary heart disease response of tracheal intubation.docVIP

 PAGE \* MERGEFORMAT 8 Esmolol on coronary heart disease response of tracheal intubation [Keywords:] esmolol; tracheal intubation; stress response; coronary heart disease Tracheal intubation, the throat and trachea by mechanical stimulation of the receptors, causing sympathetic adrenal system hyperactivity, increased release of catecholamines, causing rapid heart rate, strengthening myocardial contraction, myocardial oxygen demand, increased afterload, causing or aggravating myocardial ischemia, leading to arrhythmia, and even lead to myocardial infarction. In particular, the original heart disease, tracheal intubation during general anesthesia has resulted in the occurrence of cardiovascular events. After checking the literature and found little to prevent heart disease in clinical tracheal intubation were reported. We observed esmolol on coronary heart disease response of tracheal intubation, are as follows. 1 Subjects and methods 1.1 disease cases 40 cases of ASA - grade, no merging block off-pump coronary heart disease patients undergoing elective coronary artery bypass surgery. All the good blood pressure control in patients before surgery. Randomly divided into two groups, control group 20 patients, 12 males and 8 females, aged 61 to 79 years (mean 66.47 + -12.58 years), body weight 51 ~ 73 kg, mean (59.2 + -8.11) kg; esmolol group of 20 patients, 13 males and 7 females , aged 62 to 78 years (mean 66.5 + -12.8 years), body weight 50 ~ 79 kg, mean (64.68 + -8.9) kg. the two groups in gender, age, body mass difference was not significant. 1.2 Anesthesia Preoperative routine intramuscular injection of morphine 5 mg and scopolamine 0.3 mg, burglary after the open upper extremity vein before induction of pre-enter the compound sodium chloride solution 100 ml, radial artery puncture under local anesthesia catheter transducer pressure measurement connection. Both groups were with midazolam 0.04 mg / kg, fentanyl 6 g / kg, based on ether ac