Eucommia extract sub-chronic toxicology studies.docVIP

 PAGE \* MERGEFORMAT 16 Eucommia extract sub-chronic toxicology studies Author: Liu Feng, Jian-Wen Chen, Gong Peng-fei, YUAN Hui Keywords: Eucommia ulmoides;,, sub-chronic toxicity Abstract: Objective To study the different doses of aqueous extract of Eucommia sub-chronic toxic effects in mice, provide the basis for clinical application. Approach to experimental mice were fed with different doses of aqueous extract of Eucommia ulmoides. In the experiment, after stopping the end of 24 h, were determined to take blood hematology, blood biochemistry and major organs indicators, and for biopsy. Results gavage, the low-dose (2.06 g / kg, 0.69 g / kg) aqueous extract of Eucommia, can increase the number of mouse hemoglobin content and red blood cells (P lt;0.01), had no effect on the leukocyte count at the same time can improve mouse body weight, total protein and albumin levels (P lt;0.01), on the spleen, liver, heart, lungs, kidneys, genitals index and serum enzyme activity had no effect (Pgt; 0.05). Conclusion Eucommia extract on animal subjects was no obvious toxicity. Keywords:: Eucommia ulmoides; sub-chronic toxicity Studies on the Subchronic Toxicology of Eucommia ulmoides Extract Abstract: ObjectiveTo research the effect of Eucommia ulmoides extract solution on mice subchronic toxicity, to provide basis for clinical use.MethodsGave experiment mice different doses of Eucommia ulmoides extract solution, in mediumterm and after administration for 24 h, blood physiological, blood chemistry, the main viscera coefficient were tested.ResultsBy gastrogavage, the middle and low dose of Eucommia ulmoides extract solution improved the content hemoglobin (Hb) and red blood cell count, but had no effect on white blood cell count (P lt;0.01). It increased mice weigt, total protein content, white protein content (P lt;0.01), but had no effect on indexes of spleen, live, heart, lung, kidney, sexual organ and the activation of serum enzyme (P