Eucommia of unilateral ureteral obstruction rat kidney expression of MMP2.docVIP

 PAGE \* MERGEFORMAT 14 Eucommia of unilateral ureteral obstruction rat kidney expression of MMP2 [Abstract] [Objective] Eucommia unilateral ureteral obstruction (UUO rat kidney MMP 2 and to explore its possible mechanism. [Method] with unilateral ureteral obstruction (UUO renal interstitial fibrosis. The 32 largest mice were randomly divided into 4 groups, n = 8, sham operation group, model group, irbesartan group and gutta-percha group. irbesartan group were given irbesartan 10 mg kg-1 d-1, Eucommia Eucommia group received 6 g kg-1 d-1 treatment. After 2 weeks the rats were killed under light microscope observation of Masson and HE staining index of interstitial fibrosis, renal pathological changes and immunohistochemical kidney tissue detected by matrix metalloproteinase 2 (Matrix metal proteinase 2, MMP 2 expression. [Results] 1.UUO group compared with the sham group, BUN, Scr levels significantly increased, Eucommia group than in the UUO group showed a downward trend. The effect of irbesartan group were similar with Eucommia, and between the two groups, no significant difference (Pgt; 0.05.2. Compared with the sham group, HE staining of renal tissue was seen in group UUO renal tubular epithelial cells filled with air denaturation bubble, expansion, some atrophy, occasional necrosis, interstitial widening, a large number of inflammatory cell infiltration and interstitial fibrosis, glomerular pathology was not obvious, these changes are the Eucommia group reduced, irbesartan Eucommia group were similar pathological changes, and between the two groups, no significant difference (Pgt; 0.05.3. Compared with the sham group, Masson staining showed that the UUO group showed renal interstitial widening, a large proliferation of collagen fibers glomerular lesions is not obvious, these changes are the Eucommia group reduced Eucommia irbesartan group were similar pathological changes, and between the two groups, no significant difference (Pgt; 0.05.4.MMP 2 in t