Expression of estrogen receptor in breast cancer research progress.docVIP

 PAGE \* MERGEFORMAT 11 Expression of estrogen receptor in breast cancer research progress [Abstract] current etiology and pathogenesis of breast cancer is not entirely clear, the impact of risk factors for breast cancer and estrogen receptor (ER) status has important relations. Clinical testing has been used to evaluate patients with ER @ prognosis and choice of treatment In 1996 the program targets low expression of ER found in produce treated with tamoxifen resistance phase, and its expression is associated with breast cancer may be low. in the estrogen receptor gene and breast cancer study, researchers found the ERRNA in tolerance to tamoxifen treatment increased expression in breast cancer patients, and the ER @ and ERRNA while there may be poor clinical outcome. whether the development of breast cancer is the kind of receptors regulation of estrogen to promote tumor cell growth and the specific mechanisms still need further study. [Keywords:] breast cancer estrogen receptor gene Breast cancer (mammary carcinoma is a malignant tumor derived from epithelial tissue. More in women, ranking the second female malignancy. North American and Scandinavian high incidence of breast cancer in most countries, the annual incidence rate of 65/10 to 74 million / 10 million, mortality in the 25/10 million or more. Although the low-incidence areas of China, but in recent years with the Western lifestyle and living standards of the incidence rate showed a rising trend year by year. In some economically developed areas such as Shanghai, Beijing, the incidence of breast cancer has been ranked first in women. Cause of breast cancer is not fully understood, some risk factors have been confirmed also remains controversial. According to the research, the main risk factors are: heredity, hormones, viruses, menstrual marriage, birth and other breast-feeding, and these risk factors on breast cancer the impact of hormone receptor status with the [1]. now can be