Extracts of Erigeron persistent ocular retinal gene expression.docVIP

 PAGE \* MERGEFORMAT 12 Extracts of Erigeron persistent ocular retinal gene expression [Abstract] observed Dengzhanhua extracts (DSX persistent high intraocular pressure on intraocular pressure and retinal gene expression in rats. Methods (1 SD rats were divided into 3 groups, control group did not modeling, model group and treatment group modeling method by Akira. (2 Determination of three groups of rats immediately after surgery, postoperative day 1, every 7 days after intraocular pressure 1 month after operation. (3 rats were killed to extract the retina totalRNA , made into chips and analyzed. Results (1 rat 3 days before surgery the mean IOP was (13.44 +-1.50mm Hg, mean IOP increased immediately after 147% 1 month after the model group, the average eye pressure is 1.99 times that before surgery, the experimental group and control group the same IOP. (2 compared with the control group, model group 1 and apoptosis-related genes NGFR expression increased, compared with model group, the experimental group, NGFR downregulation. CRYGD, CRYBB3, CRYBB2 upregulated. Conclusion DSX persistent high intraocular pressure on rat retina has a protective effect. [Keywords:] retinal gene expression in persistent high intraocular pressure apoptosis Dengzhanhua [Abstract] Objective To observe the intraocular pressure and the gene expression of retina of the rat model of chronic, moderately elevated intraocular pressure (IOP by DSX drawed from Herba Erigerontis.Methods (1By the method of Akira, the rat model of chronic, moderately elevated intraocular pressure was got. (2 We monitored the intraocular pressure continuously for 3 day and made Oligo gene array.Results (1The average IOP was (13.44 +-1.50mm Hg before operation and it elevated 147% after operation.One month later, The average IOP of model group was 1.99 times than preoperation.The average IOP of test group was as same as preoperation.Conclusion DSX could protect the retina of the rat model of chronic, mode