Flavonoids aldose reductase inhibitors.docVIP

 PAGE \* MERGEFORMAT 14 Flavonoids aldose reductase inhibitors [Abstract] aldose reductase polyol pathway is a key rate-limiting enzyme, high blood sugar levels, this pathway metabolically active, and the complications of diabetes is closely related to the occurrence and deterioration. Aldose reductase inhibitors (ARIs) is the treatment of diabetic complications, one of the important drugs may be through inhibiting the polyol pathway of glucose metabolism in the rate-limiting enzyme - aldose reductase activity, reducing the accumulation of sorbitol in vivo, in order to prevent and delay the occurrence and development of diabetic complications. A detailed overview of the article Flavonoids aldose reductase inhibitor screening method, the structural characteristics of the mechanism of AR, etc., and its development prospect. [Keywords:] diabetic complications aldose reductase inhibitors, flavonoids Aldose reductase (EC. 1.1.1.21, aldose reductase, AR) is a poly-alcohol pathway of the key rate-limiting enzyme in order to restore the sexual coenzyme Ⅱ (NADPH) as a coenzyme, catalytic reduction reaction has sugar, this transformation of glucose for the corresponding reduction product of sorbitol, and then again in sorbitol dehydrogenase sorbitol oxidation under the action of the outcome of sugar, many organizations have with this approach, shown in Figure 1. In normal tissues this way and the conversion rate is very low, but blood glucose concentrations are elevated, glucose hexokinase is saturated, a large number of glucose through the aldose reductase into sorbitol, because sorbitol into fructose than the rate of Sorbitol generation rate, and the sorbitol molecules easily enter through the cell membrane into the blood circulation, and thus a large number of accumulation in the cells caused by the hypertonic effect of intracellular, cell swelling, membrane permeability changes, caused by a series of pathological changes, thus induced complications of diabetes,